At the beginning of the new year, Professor HU Zhenming, the academic leader of orthopedics at the University-Town Hospital of Chongqing Medical University, and TAN Bing, a postdoctoral researcher as the first author, published a research paper titled "Intra-Articular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy" in the authoritative international journal Advanced Composites and Hybrid Materials (Q2 by CAS).
Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation, subchondral bone remodeling, and chronic inflammation. This study explored the effectiveness of CaCO3-coated (CaCO3@ZIF@Mo-TA) ZIF-8 composite molybdenum nanomaterials as a novel treatment method for OA. In vivo studies showed that in an OA rat model, CaCO3@ZIF-8@Mo-TA significantly improved joint damage, reduced inflammation, and enhanced cartilage protection. Mechanistic studies found that nanomaterials exert antioxidant and anti-inflammatory effects by regulating key signaling pathways, including the NLRP3 inflammasome. These results indicate that ZIF-8@Mo-TA nanomaterials represent a promising new approach for treating OA.
The University-Town Hospital of CQMU places enhancing scientific research innovation and development levels at a critical position, continuously optimizing scientific research policies and incentive mechanisms by attracting talented individuals, injecting strong momentum into scientific research work. In the future, the hospital will continue to leverage its roles in scientific and technological innovation and medical services, striving towards becoming an innovative research-oriented hospital.
(Translated by AI)
